Cellosaurus cell line NPC43 (CVCL

Cellosaurus NPC43 (CVCL_UH64)

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Cell line name

NPC43

Accession

CVCL_UH64

Resource Identification Initiative

To cite this cell line use: NPC43 (RRID:CVCL_UH64)

Comments

Population: Chinese.
Virology: Contains 15-20 copies per cell of EBV genome.
Doubling time: 8 days (Note=At 22th passage), 4 days (Note=At 90th passage), 2.5 days (Note=At 200th passage) (PubMed=30405107).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Pharynx, nasopharynx; UBERON=UBERON_0001728.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Trp53Ter (c.158G>A); ClinVar=VCV000230285; Zygosity=Homozygous (PubMed=30405107).

Disease

Nasopharyngeal carcinoma (NCIt: C3871)
Nasopharyngeal carcinoma (ORDO: Orphanet_150)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

64Y

Category

Cancer cell line

STR profile

Source(s): PubMed=30405107

Markers:

Amelogenin	X
CSF1PO	13
D3S1358	18
D5S818	11
D7S820	12,13
D8S1179	11
D13S317	12
D16S539	10
D18S51	13,15
D21S11	32
FGA	22
Penta D	8
TH01	7
TPOX	8
vWA	14,16

Publications

PubMed=30405107; DOI=10.1038/s41467-018-06889-5; PMCID=PMC6220246
Wei-Tao Lin, Yim-Ling Yip, Lin Jia, Wen Deng, Hong Zheng, Wei Dai, Josephine Mun-Yee Ko, Kwok-Wai Lo, Grace Tin-Yun Chung, Kevin Yuk-Lap Yip, Sau-Dan Lee ...Show all 35 authors... , Johnny Sheung-Him Kwan, Jun Zhang, Teng-Fei Liu, Jimmy Yu-Wai Chan, Dora Lai-Wan Kwong, Victor Ho-Fun Lee, John Malcolm Nicholls, Pierre Busson, Xue-Feng Liu, Alan Kwok-Shing Chiang, Kwai-Fung Hui, Hin Kwok, Siu-Tim Cheung, Yuk-Chun Cheung, Chi-Keung Chan, Bin Li, Annie Lai-Man Cheung, Pok-Man Hau, Yuan Zhou, Chi-Man Tsang, Jaap Michiel Middeldorp, Hong-Lin Chen, Maria Li Lung, George Sai-Wah Tsao; Show fewer authors
Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma.
Nat. Commun. 9:4663.1-4663.17(2018)

DOI=10.1016/B978-0-12-814936-2.00005-5
Yim-Ling Yip, Wei-Tao Lin, Wen Deng, Chi-Man Tsang, George Sai-Wah Tsao;
Establishment of nasopharyngeal carcinoma cell lines, patient-derived xenografts, and immortalized nasopharyngeal epithelial cell lines for nasopharyngeal carcinoma and Epstein-Barr virus infection studies.
(In book chapter) Nasopharyngeal carcinoma. From etiology to clinical practice; Lee, Anne Wing-Mui & Lung, Maria Li & Ng, Wai-Tong (eds.); pp.85-107; Academic Press; New York; USA (2019)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_UH64
Cell_Model_Passport; SIDM01992

Encyclopedic resources

Wikidata; Q98128017

Entry history

Entry creation

25-Feb-2019

Last entry update

10-Apr-2025

Version number