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Cellosaurus XP23OS (CVCL_UH39)

[Text version]
Cell line name XP23OS
Synonyms Xeroderma Pigmentosum 23 OSaka
Accession CVCL_UH39
Resource Identification Initiative To cite this cell line use: XP23OS (RRID:CVCL_UH39)
Comments Population: Japanese.
Senescence: Senesces at 17 PDL (PubMed=6492896).
Misspelling: XP230S; Note=Occasionally.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:3436; ERCC4; Simple; p.Glu456Glyfs*8 (c.1364dupA); Zygosity=Hemizygous or homozygous (PubMed=9580660).
Disease Xeroderma pigmentosum, complementation group F (NCIt: C3968)
Xeroderma pigmentosum (ORDO: Orphanet_910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 45Y
Category Finite cell line
Publications

PubMed=6492896; DOI=10.1016/0047-6374(84)90044-7
James Edward Cleaver;
DNA repair deficiencies and cellular senescence are unrelated in xeroderma pigmentosum cell lines.
Mech. Ageing Dev. 27:189-196(1984)

PubMed=3834095; DOI=10.1269/jrr.26.443
Yoshisada Fujiwara, Masamitsu Ichihashi, Yoshihiko Uehara, Akira Matsumoto, Yoko Yamamoto, Yoshio Kano, Yoshimasa Tanakura;
Xeroderma pigmentosum groups C and F: additional assignments and a review of the subjects in Japan.
J. Radiat. Res. 26:443-449(1985)

PubMed=4066782; DOI=10.1242/jcs.76.1.115
Robert T. Johnson, Shoshana Squires, George C. Elliott, Gordon L.E. Koch, Andrew J. Rainbow;
Xeroderma pigmentosum D-HeLa hybrids with low and high ultraviolet sensitivity associated with normal and diminished DNA repair ability, respectively.
J. Cell Sci. 76:115-133(1985)

PubMed=9580660; DOI=10.1093/hmg/7.6.969
Yasuhiro Matsumura, Chikako Nishigori, Takashi Yagi, Sadao Imamura, Hiraku Takebe;
Characterization of molecular defects in xeroderma pigmentosum group F in relation to its clinically mild symptoms.
Hum. Mol. Genet. 7:969-974(1998)

PubMed=20221251; DOI=10.1371/journal.pgen.1000871; PMCID=PMC2832669
Anwaar Ahmad, Jacqueline Henriette Enzlin, Nikhil R. Bhagwat, Nils Wijgers, Anja Raams, Esther Appledoorn, Arjan F. Theil, Jan Hendrik Jozef Hoeijmakers, Wim Vermeulen, Nicolaas G.J. Jaspers, Orlando David Scharer, Laura J. Niedernhofer;
Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.
PLoS Genet. 6:e1000871.1-e1000871.11(2010)

Cross-references
Cell line collections (Providers) JCRB; KURB1087
JCRB; KURB1088
Encyclopedic resources Wikidata; Q98135566
Entry history
Entry creation13-Nov-2018
Last entry update19-Dec-2024
Version number11