Cellosaurus cell line fALS (CVCL

Cross-references
Cell line name	fALS
Accession	CVCL_UF87
Resource Identification Initiative	To cite this cell line use: fALS (RRID:CVCL_UF87)
Comments	Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:11179; SOD1; Simple; p.Ala5Val (c.14C>T) (A4V); ClinVar=VCV000014763; Zygosity=Unspecified (PubMed=24379375).
Disease	Amyotrophic lateral sclerosis 1 (NCIt: C168749) Amyotrophic lateral sclerosis (ORDO: Orphanet_803)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	40Y
Category	Finite cell line
Publications	PubMed=24379375; DOI=10.1073/pnas.1314085111; PMCID=PMC3896192 Kathrin Meyer, Laura Ferraiuolo, Carlos J. Miranda, Shibi B. Likhite, Sohyun Lee McElroy, Samantha Renusch, Dara Ditsworth, Clotilde Lagier-Tourenne, Richard A. Smith, John Ravits, Arthur H.M. Burghes ...Show all 15 authors... , Pamela Jean Shaw, Don Whitefield Cleveland, Stephen J. Kolb, Brian K. Kaspar; Show fewer authors Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS. Proc. Natl. Acad. Sci. U.S.A. 111:829-832(2014)
Encyclopedic resources	Wikidata; Q93549602
Entry history
Entry creation	13-Nov-2018
Last entry update	19-Dec-2024
Version number	9