Cell line name |
DIF8 |
Accession |
CVCL_UF14 |
Resource Identification Initiative |
To cite this cell line use: DIF8 (RRID:CVCL_UF14) |
Comments |
Population: African; Kenyan. Characteristics: Resistant to both the antiviral and antiproliferative actions of interferons. Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: B-cell; CL=CL_0000236. |
Sequence variations |
- Gene fusion; HGNC; HGNC:5477; IGH + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGH (from parent cell line).
- Mutation; HGNC; HGNC:914; B2M; Simple; p.Met1Ile (c.3G>C); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ala5_Ala80del (c.14_241del228); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
|
Disease |
EBV-related Burkitt lymphoma (NCIt: C27694) Burkitt lymphoma (ORDO: Orphanet_543) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0008 (Daudi) |
Sex of cell |
Male |
Age at sampling |
16Y |
Category |
Cancer cell line |
Publications | PubMed=2580049; DOI=10.1099/0022-1317-66-4-787 Michel Dron, Michael G. Tovey, Pierre Eid; Isolation of Daudi cells with reduced sensitivity to interferon. III Interferon-induced proteins in relation to the phenotype of interferon resistance. J. Gen. Virol. 66:787-795(1985) PubMed=2937878; DOI=10.1099/0022-1317-67-4-663 Michel Dron, Michael G. Tovey, Gilles Uze; Isolation of Daudi cells with reduced sensitivity to interferon. IV Characterization of clones with altered binding of human interferon alpha subspecies. J. Gen. Virol. 67:663-669(1986) PubMed=3785169; DOI=10.1128/mcb.6.5.1374-1378.1986; PMCID=PMC367660 Michel Dron, Nazanine Modjtahedi, Olivier Brison, Michael G. Tovey; Interferon modulation of c-myc expression in cloned Daudi cells: relationship to the phenotype of interferon resistance. Mol. Cell. Biol. 6:1374-1378(1986) PubMed=8301159; DOI=10.1089/jir.1993.13.377 Michel Dron, Michael G. Tovey; Interferon-resistant Daudi cells are deficient in interferon-alpha-induced ISGF3 alpha activation, but remain sensitive to the interferon-alpha-induced increase in ISGF3 gamma content. J. Interferon Res. 13:377-383(1993) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_UF14
|
Encyclopedic resources |
Wikidata; Q93527520
|
Entry history |
Entry creation | 13-Nov-2018 |
Last entry update | 19-Dec-2024 |
Version number | 12 |
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