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Cellosaurus LREX' (CVCL_UD76)

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Cell line name LREX'
Synonyms LnCaP/AR Resistant to Enzalutamide Xenograft derived
Accession CVCL_UD76
Resource Identification Initiative To cite this cell line use: LREX' (RRID:CVCL_UD76)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_68534; Enzalutamide (Xtandi; MDV-3100).
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=24315100; DOI=10.1016/j.cell.2013.11.012; PMCID=PMC3932525
Vivek K. Arora, Emily Schenkein, Rajmohan Murali, Sumit K. Subudhi, John Wongvipat, Minna D. Balbas, Neel Shah, Ling Cai, Eleni Efstathiou, Christopher J. Logothetis, De-You Zheng, Charles Lazelle Sawyers;
Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade.
Cell 155:1309-1322(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UD76
Encyclopedic resources Wikidata; Q95983040
Entry history
Entry creation13-Nov-2018
Last entry update19-Dec-2024
Version number10