Cellosaurus cell line Nalm-6-MSH+/TK+/- (CVCL

Cellosaurus Nalm-6-MSH+/TK+/- (CVCL_UD71)

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Cell line name

Nalm-6-MSH+/TK+/-

Accession

CVCL_UD71

Resource Identification Initiative

To cite this cell line use: Nalm-6-MSH+/TK+/- (RRID:CVCL_UD71)

Comments

Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:11830; TK1 (Note=1 of 2 alleles).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:7325; MSH2 (Note=Exons 9 to 16).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Sequence variations

Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).

Disease

Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_J365 (Nalm-6-MSH+)
Children:

CVCL_J376 (POLH KO)	CVCL_JH01 (POLK CD)	CVCL_JH05 (POLK KO)
CVCL_JH00 (POLK KO-CD comp)	CVCL_JH07 (POLK KO-comp)	CVCL_JG97 (POLK KO-POLH-/-)
CVCL_JH09 (POLZ D2781N)	CVCL_JH04 (POLZ L2618F)	CVCL_M250 (POLZ L2618M)
CVCL_JH06 (POLZ Y2779F)	CVCL_JG99 (POLZ Y2779F-POLH+/-)	CVCL_JG98 (POLZ Y2779F-POLK+/-)

Sex of cell

Male

Age at sampling

19Y