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Cellosaurus LM-MEL-3 (CVCL_UC18)

[Text version]
Cell line name LM-MEL-3
Synonyms LM-Mel-3; Ludwig Melbourne-MELanoma-3
Accession CVCL_UC18
Resource Identification Initiative To cite this cell line use: LM-MEL-3 (RRID:CVCL_UC18)
Comments Part of: Ludwig Institute for Cancer Research Melbourne melanoma cell line panel.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Miscellaneous: MAP2K1 mutation, metastatic site and STR profile from personal communication of Cardwell, Tracy.
Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23527996).
  • Mutation; HGNC; HGNC:6840; MAP2K1; Simple; p.Pro124Leu (c.371C>T); ClinVar=VCV000040744; Zygosity=Heterozygous (Direct_author_submission).
HLA typing Source: PubMed=23527996
Class I
HLA-AA*01:01,24:02
HLA-BB*07:02,08:01
HLA-CC*07:01,07:02
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO13
D5S81812
D7S82010,12
D13S31711,12
D16S53913,14
D21S1129
TH017,9.3
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=18957296; DOI=10.1016/j.jim.2008.09.023
Nektaria Dimopoulos, Heather M. Jackson, Lisa M. Ebert, Philippe Guillaume, Immanuel F. Luescher, Gerd Ritter, Wei-San Chen;
Combining MHC tetramer and intracellular cytokine staining for CD8(+) T cells to reveal antigenic epitopes naturally presented on tumor cells.
J. Immunol. Methods 340:90-94(2009)

PubMed=23527996; DOI=10.1111/pcmr.12097
Andreas Behren, Matthew Anaka, Pu-Han Lo, Laura J. Vella, Ian D. Davis, Jenny Catimel, Tracy Cardwell, Craig Gedye, Christopher Hudson, Rodica Stan, Jonathan S. Cebon;
The Ludwig Institute for Cancer Research Melbourne melanoma cell line panel.
Pigment Cell Melanoma Res. 26:597-600(2013)

PubMed=27852308; DOI=10.1186/s12943-016-0554-y; PMCID=PMC5112703
Miles C. Andrews, Joseph Cursons, Daniel Glyn Hurley, Matthew Anaka, Jonathan S. Cebon, Andreas Behren, Edmund John Crampin;
Systems analysis identifies miR-29b regulation of invasiveness in melanoma.
Mol. Cancer 15:72.1-72.20(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UC18
Encyclopedic resources Wikidata; Q95982518
Gene expression databases ArrayExpress; E-MTAB-1496
GEO; GSM2371743
Entry history
Entry creation13-Nov-2018
Last entry update10-Apr-2025
Version number13