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Cellosaurus WC035i-SOD1-D90D (CVCL_UA50)

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Cell line name WC035i-SOD1-D90D
Synonyms WiCell; wc035i-sod1-d90d
Accession CVCL_UA50
Resource Identification Initiative To cite this cell line use: WC035i-SOD1-D90D (RRID:CVCL_UA50)
Comments Population: Caucasian.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:11179; SOD1; Simple_corrected; p.Asp91Ala (c.272A>C) (D90A); ClinVar=VCV000014766; Zygosity=Heterozygous; Note=By TALEN (PubMed=24704493).
Disease Amyotrophic lateral sclerosis 1 (NCIt: C168749)
Amyotrophic lateral sclerosis (ORDO: Orphanet_803)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_UA49 (WC034i-SOD1-D90A)
Sex of cell Female
Age at sampling 50Y
Category Induced pluripotent stem cell
STR profile Source(s): PubMed=24704493

Markers:
AmelogeninX
CSF1PO9,11
D5S8189,11
D7S8208,9
D8S117910,15
D13S3179,12
D16S5399,12
FGA21,22
Penta D9,12
Penta E10,11
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=24704493; DOI=10.1016/j.stem.2014.02.004; PMCID=PMC4230530
Hong Chen, Kun Qian, Zhong-Wei Du, Jing-Yuan Cao, Andrew Petersen, Hui-Sheng Liu, Lisle W. Blackbourn 4th, Cindy Tzu-Ling Huang, Anthony Errigo, Ying-Nan Yin, Jian-Feng Lu ...Show all 13 authors... , Melvin Ayala, Su-Chun Zhang; Show fewer authors
Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons.
Cell Stem Cell 14:796-809(2014)

Cross-references
Encyclopedic resources Wikidata; Q98134815
Entry history
Entry creation13-Nov-2018
Last entry update19-Dec-2024
Version number10