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Cellosaurus H4-C99 (CVCL_U993)

[Text version]
Cell line name H4-C99
Synonyms H4-APP-C99
Accession CVCL_U993
Resource Identification Initiative To cite this cell line use: H4-C99 (RRID:CVCL_U993)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:620; APP (Note=With p.Met1_Met671del = C99).
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1239 (H4)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Publications

PubMed=20143425; DOI=10.1002/jnr.22356
San Sook Chae, Chul Bae Yoo, Chulman Jo, Sang-Moon Yun, Sangmee Ahn Jo, Young Ho Koh;
Caspases-2 and -8 are involved in the presenilin1/gamma-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis.
J. Neurosci. Res. 88:1926-1933(2010)

Cross-references
Anatomy/cell type resources BTO; BTO_0005095
Encyclopedic resources Wikidata; Q54872132
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number12