| Cell line name |
6T-CEM20 |
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| Synonyms |
6T-CEM-20; 6-T CEM-20; 6TCEM20 |
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| Accession |
CVCL_U293 |
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| Resource Identification Initiative |
To cite this cell line use: 6T-CEM20 (RRID:CVCL_U293) |
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| Comments |
Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8295.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_6869 (6T-CEM) |
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| Sex of cell |
Female |
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| Age at sampling |
3Y11M |
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| Category |
Cancer cell line |
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| Publications | PubMed=6234996; DOI=10.1016/0008-8749(84)90128-X
Lau C.Y., Budz-Tymkewycz S., Wang E.Y., Ishaque A.
A mutant human T-cell line producing immunosuppressive factor(s).
Cell. Immunol. 87:35-52(1984) Patent=US4705687
Lau C.Y.
Treatment of autoimmune diseases such as rheumatoid arthritis with suppressor factor.
Patent number US4705687, 10-Nov-1987 Patent=US4728614
Lau C.Y.
Mutant human T cell line producing immunosuppressive factor and method for obtaining such mutants.
Patent number US4728614, 01-Mar-1988 |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_U293
|
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| Encyclopedic resources |
Wikidata; Q54604614
|
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| Entry history |
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| Entry creation | 03-Feb-2014 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 20 |
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