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Cellosaurus AG11395 (CVCL_U281)

[Text version]
Cell line name AG11395
Synonyms WS780
Accession CVCL_U281
Resource Identification Initiative To cite this cell line use: AG11395 (RRID:CVCL_U281)
Comments Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: DNA methylation analysis.
Misspelling: AG11385; GEO=GSM1052419; PubMed=23257959.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; 12791; WRN; Simple; p.Arg369Ter (c.1105C>T) (c.1336C>T); ClinVar=VCV000005449; Zygosity=Homozygous (PubMed=9230208; Coriell=AG11395).
Disease Werner syndrome (NCIt: C3447)
Werner syndrome (ORDO: Orphanet_902)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_U282 (AG00780)
Sex of cell Male
Age at sampling 60Y
Category Transformed cell line

PubMed=1671011; DOI=10.1016/0014-4827(91)90054-X
Saito H., Moses R.E.
Immortalization of Werner syndrome and progeria fibroblasts.
Exp. Cell Res. 192:373-379(1991)

National Institute on Aging
1994 catalog of cell lines. NIA Aging Cell Repository.
(In) Institute for Medical Research (Camden, N.J.); pp.1-351; National Institutes of Health; Bethesda (1994)

Bennett S.E., Umar A., Oshima J., Monnat R.J. Jr., Kunkel T.A.
Mismatch repair in extracts of Werner syndrome cell lines.
Cancer Res. 57:2956-2960(1997)

PubMed=10606667; DOI=10.1093/nar/28.2.648
Moser M.J., Kamath-Loeb A.S., Jacob J.E., Bennett S.E., Oshima J., Monnat R.J. Jr.
WRN helicase expression in Werner syndrome cell lines.
Nucleic Acids Res. 28:648-654(2000)

Henson J.D.
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006), University of Sydney, Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M., Pickett H.A., Reddel R.R.
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

PubMed=23257959; DOI=10.4161/epi.23366
Heyn H., Moran S., Esteller M.
Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford progeria and Werner syndrome.
Epigenetics 8:28-33(2013)

Cell line collections (Providers) Coriell; AG11395
Cell line databases/resources CLO; CLO_0021582
Encyclopedic resources Wikidata; Q54743912
Gene expression databases GEO; GSM1052419
Entry history
Entry creation03-Feb-2014
Last entry update30-Jan-2024
Version number20