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Cellosaurus MR10-1 (CVCL_U181)

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Cell line name MR10-1
Accession CVCL_U181
Resource Identification Initiative To cite this cell line use: MR10-1 (RRID:CVCL_U181)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_U209 (HeLa S3 mer-)
Children:
CVCL_U185 (ACr41)CVCL_U186 (ACr42)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): RCB=RCB0507

Markers:
AmelogeninX
CSF1PO9,10
D5S81811,12
D7S8208
D16S5399,10
TH017
TPOX8,12
vWA15,18

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Publications

PubMed=3608093; DOI=10.1093/carcin/8.8.1109
Ryoji Ishida, Taijo Takahashi;
N-methyl-N'-nitro-N-nitrosoguanidine-resistant HeLa S3 cells still have little O6-methylguanine-DNA methyltransferase activity and are hypermutable by alkylating agents.
Carcinogenesis 8:1109-1113(1987)

PubMed=3163531; DOI=10.1093/carcin/9.6.1079
Ryoji Ishida, Taijo Takahashi;
Increased O6-methylguanine-DNA methyltransferase activity and reduced mutability in 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl) 3-nitrosourea-resistant HeLa S3 cells.
Carcinogenesis 9:1079-1083(1988)

PubMed=2372878; DOI=10.1093/carcin/11.7.1209
Ryoji Ishida, Kazuhiko R. Utsumi;
Differences in induction of sister chromatid exchanges in MNNG-resistant HeLa S3 Mer- cell lines.
Carcinogenesis 11:1209-1212(1990)

Cross-references
Cell line collections (Providers) RCB; RCB0507
Cell line databases/resources CLO; CLO_0050917
Encyclopedic resources Wikidata; Q54906569
Entry history
Entry creation03-Feb-2014
Last entry update10-Apr-2025
Version number16