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Cellosaurus NB4-S1 (CVCL_U086)

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Cell line name NB4-S1
Accession CVCL_U086
Resource Identification Initiative To cite this cell line use: NB4-S1 (RRID:CVCL_U086)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_15367; All-trans-retinoic acid (ATRA; Tretinoin).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
Children:
CVCL_U087 (NB4-DR2)CVCL_U088 (NB4-DR3)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line
Publications

PubMed=9342843; DOI=10.1046/j.1432-0436.1997.6150321.x
Kathryn Nason-Burchenal, Wolfgang Maerz, Joan Albanell, Janet J. Allopenna, Patrick Martin, Malcolm A.S. Moore, Ethan Dmitrovsky;
Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization.
Differentiation 61:321-331(1997)

PubMed=9716606; DOI=10.1182/blood.V92.5.1758
Kathryn Nason-Burchenal, Janet J. Allopenna, Agnes Begue, Dominique Stehelin, Ethan Dmitrovsky, Patrick Martin;
Targeting of PML/RARalpha is lethal to retinoic acid-resistant promyelocytic leukemia cells.
Blood 92:1758-1767(1998)

Cross-references
Cell line databases/resources cancercelllines; CVCL_U086
TOKU-E; 4157
Encyclopedic resources Wikidata; Q54907534
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number20