Cell line name |
NB4-DR1 |
Synonyms |
NB4-R1 |
Accession |
CVCL_U085 |
Resource Identification Initiative |
To cite this cell line use: NB4-DR1 (RRID:CVCL_U085) |
Comments |
Population: Caucasian. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. |
Sequence variations |
- Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
|
Disease |
Acute promyelocytic leukemia with PML-RARA (NCIt: C3182) Acute promyelocytic leukemia (ORDO: Orphanet_520) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0005 (NB4) |
Sex of cell |
Female |
Age at sampling |
23Y |
Category |
Cancer cell line |
Publications | PubMed=9342843; DOI=10.1046/j.1432-0436.1997.6150321.x Kathryn Nason-Burchenal, Wolfgang Maerz, Joan Albanell, Janet J. Allopenna, Patrick Martin, Malcolm A.S. Moore, Ethan Dmitrovsky; Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization. Differentiation 61:321-331(1997) PubMed=9716606; DOI=10.1182/blood.V92.5.1758 Kathryn Nason-Burchenal, Janet J. Allopenna, Agnes Begue, Dominique Stehelin, Ethan Dmitrovsky, Patrick Martin; Targeting of PML/RARalpha is lethal to retinoic acid-resistant promyelocytic leukemia cells. Blood 92:1758-1767(1998) PubMed=11704857; DOI=10.1038/sj.onc.1204863 Mathilde J.S. Roussel, Michel Lanotte; Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes. Oncogene 20:7287-7291(2001) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_U085
|
Encyclopedic resources |
Wikidata; Q54907529
|
Entry history |
Entry creation | 03-Feb-2014 |
Last entry update | 19-Dec-2024 |
Version number | 18 |
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