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Cellosaurus NB4-AsR (CVCL_U080)

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Cell line name NB4-AsR
Synonyms NB4-dT-AsR1
Accession CVCL_U080
Resource Identification Initiative To cite this cell line use: NB4-AsR (RRID:CVCL_U080)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_30621; Diarsenic trioxide (ATO; As2O3).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line
Publications

PubMed=9596679; DOI=10.1182/blood.V91.11.4300
Maurizio Gianni, Marcel H.M. Koken, Mounira K. Chelbi-Alix, Gerard Benoit, Michel Lanotte, Zhu Chen, Hugues de The;
Combined arsenic and retinoic acid treatment enhances differentiation and apoptosis in arsenic-resistant NB4 cells.
Blood 91:4300-4310(1998)

PubMed=11704857; DOI=10.1038/sj.onc.1204863
Mathilde J.S. Roussel, Michel Lanotte;
Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.
Oncogene 20:7287-7291(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_U080
Encyclopedic resources Wikidata; Q54907528
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number19