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Cellosaurus SL0006 (CVCL_TZ90)

[Text version]
Cell line name SL0006
Accession CVCL_TZ90
Resource Identification Initiative To cite this cell line use: SL0006 (RRID:CVCL_TZ90)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-6663.
Population: Caucasian.
Characteristics: Useful for the production of E1-deleted adenovirus (rAd) vectors.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04495; Human adenovirus C serotype 5 DNA polymerase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03255; Human adenovirus C serotype 5 E1A protein (Note=With p.Ile4_Glu25del and p.Ser111_Thr123del = dl01/07).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03246; Human adenovirus C serotype 5 E1B 19 kDa protein.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03243; Human adenovirus C serotype 5 E1B 55 kDa protein.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=16246392; DOI=10.1016/j.virol.2005.09.029
John A. Howe, Peter Pelka, Douglas Antelman, Chris Wilson, Doug Cornell, Wendy Hancock, Murali Ramachandra, Jenny Avanzini, Mark Horn, Ken N. Wills, Suganto Sutjipto, Robert Orville Ralston 2nd;
Matching complementing functions of transformed cells with stable expression of selected viral genes for production of E1-deleted adenovirus vectors.
Virology 345:220-230(2006)

Patent=US7851218
John A. Howe, Ken N. Wills, Robert Orville Ralston 2nd, Scott Joseph Sherrill;
Cell lines for production of replication-defective adenovirus.
Patent number US7851218, 14-Dec-2010

Cross-references
Cell line databases/resources cancercelllines; CVCL_TZ90
Encyclopedic resources Wikidata; Q54954829
Entry history
Entry creation14-May-2018
Last entry update14-Aug-2025
Version number15