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Cellosaurus SL0003 (CVCL_TZ89)

[Text version]
Cell line name SL0003
Synonyms A549 E1Adl01/07-4-E1B-55K-2
Accession CVCL_TZ89
Resource Identification Initiative To cite this cell line use: SL0003 (RRID:CVCL_TZ89)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-6231.
Population: Caucasian.
Characteristics: Useful for the production of E1-deleted adenovirus (rAd) vectors.
Transfected with: UniProtKB; P03255; Adenovirus 5 E1A protein (with p.Ile4_Glu25del and p.Ser111_Thr123del = dl01/07).
Transfected with: UniProtKB; P03243; Adenovirus 5 E1B 55 kDa protein.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=16246392; DOI=10.1016/j.virol.2005.09.029
Howe J.A., Pelka P., Antelman D., Wilson C., Cornell D., Hancock W., Ramachandra M., Avanzini J., Horn M., Wills K.N., Sutjipto S., Ralston R.O. II
Matching complementing functions of transformed cells with stable expression of selected viral genes for production of E1-deleted adenovirus vectors.
Virology 345:220-230(2006)

Patent=US7851218
Howe J.A., Wills K.N., Ralston R.O. II, Sherrill S.J.
Cell lines for production of replication-defective adenovirus.
Patent number US7851218, 14-Dec-2010

Cross-references
Cell line collections (Providers) ATCC; PTA-6231
Cell line databases/resources cancercelllines; CVCL_TZ89
Encyclopedic resources Wikidata; Q54954828
Entry history
Entry creation14-May-2018
Last entry update05-Oct-2023
Version number10