Cellosaurus cell line HAP1 RIPK2 (-) (CVCL

Cellosaurus HAP1 RIPK2 (-) (CVCL_TJ12)

Cross-references
Cell line name	HAP1 RIPK2 (-)
Synonyms	HZGHC000028c005; RIPK2 knockout cell line 5bp deletion
Accession	CVCL_TJ12
Resource Identification Initiative	To cite this cell line use: HAP1 RIPK2 (-) (RRID:CVCL_TJ12)
Comments	Group: Haploid karyotype cell line. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:10020; RIPK2. Omics: Transcriptomics; RNAseq. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease	Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174) Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_Y019 (HAP1)
Sex of cell	Male
Age at sampling	40Y
Category	Cancer cell line
Publications	PubMed=31659326; DOI=10.1038/s41592-019-0614-5 Arne H. Smits, Frederik Ziebell, Gerard Joberty, Nico Zinn, William F. Mueller, Sandra Clauder-Munster, Dirk Eberhard, Maria Falth Savitski, Paola Grandi, Petra Jakob, Anne-Marie Michon ...Show all 18 authors... , Hanice Sun, Karen Tessmer, Tilmann Burckstummer, Marcus Bantscheff, Lars M. Steinmetz, Gerard Drewes, Wolfgang Huber; Show fewer authors Biological plasticity rescues target activity in CRISPR knock outs. Nat. Methods 16:1087-1093(2019)
Cell line collections (Providers)	Horizon_Discovery; HZGHC000028c005
Encyclopedic resources	Wikidata; Q54879572
Gene expression databases	ArrayExpress; E-MTAB-7061
Proteomic databases	PRIDE; PXD010335
Entry history
Entry creation	14-May-2018
Last entry update	10-Apr-2025
Version number	13