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Cellosaurus HAP1 PPP2R5D (-) (CVCL_TG11)

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Cell line name HAP1 PPP2R5D (-)
Synonyms HZGHC003155c003; PPP2R5D knockout cell line 5bp deletion
Accession CVCL_TG11
Resource Identification Initiative To cite this cell line use: HAP1 PPP2R5D (-) (RRID:CVCL_TG11)
Comments Group: Haploid karyotype cell line.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:9312; PPP2R5D.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Y019 (HAP1)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Publications

PubMed=39935523; DOI=10.12688/f1000research.145146.2; PMCID=PMC11811605
Riham Ayoubi, Maryam Fotouhi, Charles Alende, Kathleen Southern, Carl Laflamme;
ABIF Consortium
NeuroSGC/YCharOS/EDDU Collaborative Group
A guide to selecting high-performing antibodies for serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) for use in western blot, immunoprecipitation and immunofluorescence.
F1000Research 13:1.1-1.18(2024)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HZGHC003155c003
Cell line databases/resources cancercelllines; CVCL_TG11
Encyclopedic resources Wikidata; Q54877194
Entry history
Entry creation14-May-2018
Last entry update10-Apr-2025
Version number12