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Cellosaurus KH OS R2 (CVCL_T432)

[Text version]
Cell line name KH OS R2
Synonyms KHOSR2; KHOS(R2); KHOS R2; KHOSMR
Accession CVCL_T432
Resource Identification Initiative To cite this cell line use: KH OS R2 (RRID:CVCL_T432)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Transformant: NCBI_TaxID; 11808; Kirsten murine sarcoma virus (Ki-MSV).
Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_T431 (KH OS R1)
Children:
CVCL_T433 (KH OS R3)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
Publications

PubMed=17096323; DOI=10.1002/ijc.22327
Magda Lourda, Ioannis P. Trougakos, Esftathios S. Gonos;
Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of clusterin/apolipoprotein J.
Int. J. Cancer 120:611-622(2007)

PubMed=19638450; DOI=10.1158/1535-7163.MCT-09-0115; PMCID=PMC2766237
Zhen-Feng Duan, Edwin Choy, David C. Harmon, Cao Yang, Keinosuke Ryu, Joseph H. Schwab, Henry J. Mankin, Francis John Hornicek;
Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.
Mol. Cancer Ther. 8:2122-2130(2009)

PubMed=24866169; DOI=10.1158/2326-6066.CIR-13-0224; PMCID=PMC4082476
Jacson K. Shen, Gregory M. Cote, Edwin Choy, Pei Yang, David C. Harmon, Joseph H. Schwab, Gunnlaugur Petur Nielsen, Ivan Chebib, Soldano Ferrone, Xin-Hui Wang, Yang-Yang Wang ...Show all 14 authors... , Henry J. Mankin, Francis John Hornicek, Zhen-Feng Duan; Show fewer authors
Programmed cell death ligand 1 expression in osteosarcoma.
Cancer Immunol. Res. 2:690-698(2014)

PubMed=25236161; DOI=10.1186/1471-2407-14-681; PMCID=PMC4177239
Zhen-Feng Duan, Jian-Ming Zhang, Shu-Nan Ye, Jacson K. Shen, Edwin Choy, Gregory M. Cote, David C. Harmon, Henry J. Mankin, Ying-Qi Hua, Yu Zhang, Nathanael S. Gray, Francis John Hornicek;
A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.
BMC Cancer 14:681.1-681.11(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_T432
Encyclopedic resources Wikidata; Q54899847
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number16