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Cellosaurus W12 [Human keratinocyte] (CVCL_T290)

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Cell line name W12 [Human keratinocyte]
Accession CVCL_T290
Resource Identification Initiative To cite this cell line use: W12 [Human keratinocyte] (RRID:CVCL_T290)
Comments Virology: At early passages contains about 100 HPV16 episomes per cell (PubMed=7707525).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Donor information: Established from a patient suffering from a low-grade squamous intraepithelial lesion (LG-SIL) (PubMed=2467886).
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_T291 (S12 [Human keratinocyte])CVCL_D6N8 (W12 clone 20822)CVCL_D6N9 (W12 clone 20850)
CVCL_D6NA (W12 clone 20861)CVCL_D6NB (W12 clone 20862)CVCL_D6N7 (W12 clone 20863)
Sex of cell Female
Age at sampling 22Y
Category Transformed cell line
Publications

PubMed=2467886; DOI=10.1002/ijc.2910430422
Margaret Anne Stanley, Helena M. Browne, Mark Appleby, Anthony Charles Minson;
Properties of a non-tumorigenic human cervical keratinocyte cell line.
Int. J. Cancer 43:672-676(1989)

PubMed=7707525; DOI=10.1128/JVI.69.5.2989-2997.1995; PMCID=PMC188998
Saewha Jeon, B. Lynn Allen-Hoffmann, Paul F. Lambert;
Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells.
J. Virol. 69:2989-2997(1995)

PubMed=16505361; DOI=10.1073/pnas.0600078103; PMCID=PMC1383496
Mark R. Pett, M. Trent Herdman, Roger D. Palmer, Giles See How Yeo, Mahmud K.K. Shivji, Margaret Anne Stanley, Nicholas Coleman;
Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response.
Proc. Natl. Acad. Sci. U.S.A. 103:3822-3827(2006)

Cross-references
Encyclopedic resources Wikidata; Q54993456
Entry history
Entry creation03-Feb-2014
Last entry update10-Sep-2024
Version number16