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Cellosaurus RT4v6 (CVCL_T027)

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Cell line name RT4v6
Synonyms RT4V6; RT-4-v6
Accession CVCL_T027
Resource Identification Initiative To cite this cell line use: RT4v6 (RRID:CVCL_T027)
Comments Population: Caucasian.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene fusion; HGNC; HGNC:3690; FGFR3 + HGNC; HGNC:11524; TACC3; Name(s)=FGFR3-TACC3 (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:12362; TSC1; Simple; p.Leu557Cysfs*72 (c.1669delC); ClinVar=VCV000048811; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0036 (RT-4)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=23175184; DOI=10.1038/cdd.2012.140; PMCID=PMC3569985
Goodwin G. Jinesh, Woonyoung Choi, Jay Bakul Shah, Eugene K. Lee, Daniel Levi Willis, Ashish M. Kamat;
Blebbishields, the emergency program for cancer stem cells: sphere formation and tumorigenesis after apoptosis.
Cell Death Differ. 20:382-395(2013)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Tahlita C.M. Zuiverloon, Florus C. de Jong, James C. Costello, Dan Theodorescu;
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_T027
Encyclopedic resources Wikidata; Q54951368
Polymorphism and mutation databases Cosmic; 1938696
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number15