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Cellosaurus TCam-2 (CVCL_T012)

[Text version]
Cell line name TCam-2
Synonyms TCAM-2; TCam 2; T-CAM2; TCam2; T-CAM
Accession CVCL_T012
Resource Identification Initiative To cite this cell line use: TCam-2 (RRID:CVCL_T012)
Comments Population: Japanese.
Doubling time: 55.3 hours (Note=At 10th passage) (PubMed=8394948).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Testis; UBERON=UBERON_0000473.
Disease Testicular seminoma (NCIt: C7328)
Testicular seminomatous germ cell tumor (ORDO: Orphanet_842)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=8394948; DOI=10.5980/jpnjurol1989.84.1211
Yoshihito Mizuno, Akinobu Gotoh, Sadao Kamidono, Sohei Kitazawa;
Establishment and characterization of a new human testicular germ cell tumor cell line (TCam-2).
Nihon Hinyokika Gakkai Zasshi 84:1211-1218(1993)

PubMed=18008088; DOI=10.1007/s00441-007-0527-y
Dawid Eckert, Daniel Nettersheim, Lukas Carl Heukamp, Sohei Kitazawa, Katharina Biermann, Hubert Schorle;
TCam-2 but not JKT-1 cells resemble seminoma in cell culture.
Cell Tissue Res. 331:529-538(2008)

PubMed=18050305; DOI=10.1002/gcc.20520
Jeroen de Jong, Hans Stoop, Ad J.M. Gillis, Remko Hersmus, Ruud J.H.L.M. van Gurp, Gert-Jan M. van de Geijn, Ellen van Drunen, H. Berna Beverloo, Dominik Thomas Schneider, Jon K. Sherlock, John Baeten ...Show all 16 authors... , Sohei Kitazawa, Everardus Johannes Jacobus van Zoelen, Kees van Roozendaal, J. Wolter Oosterhuis, Leendert H.J. Looijenga; Show fewer authors
Further characterization of the first seminoma cell line TCam-2.
Genes Chromosomes Cancer 47:185-196(2008)

PubMed=20607849; DOI=10.1002/gcc.20799
Neil C. Goddard, Alan McIntyre, Duncan Charles Gilbert, Sohei Kitazawa, Janet M. Shipley;
No evidence for V600E BRAF mutation in the seminoma cell line TCam-2.
Genes Chromosomes Cancer 49:963-966(2010)

PubMed=21668453; DOI=10.1111/j.1365-2605.2011.01170.x
Julia C. Young, Anjali Jaiprakash, Sridurga Mithraprabhu, Catherine Itman, Riko Kitazawa, Leendert H.J. Looijenga, Kate Lakoski Loveland;
TCam-2 seminoma cell line exhibits characteristic foetal germ cell responses to TGF-beta ligands and retinoic acid.
Int. J. Androl. 34:e204-e217(2011)

PubMed=23374840; DOI=10.1016/j.urology.2012.09.029; PMCID=PMC4179199
Sarah May Russell, Melissa G. Lechner, Anusuya A. Mokashi, Carolina Megiel, Julie K. Jang, Clive R. Taylor, Leendert H.J. Looijenga, Christopher Alexander French, Alan L. Epstein;
Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1.
Urology 81:464.e1-464.e9(2013)

PubMed=24812411; DOI=10.1158/1078-0432.CCR-13-2868
Darren R. Feldman, Gopa Iyer, Lindsay Van Alstine, Sujata Patil, Hikmat Al-Ahmadie, Victor E. Reuter, George J. Bosl, Raju S.K. Chaganti, David B. Solit;
Presence of somatic mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in cisplatin-resistant germ cell tumors.
Clin. Cancer Res. 20:3712-3720(2014)

PubMed=34153645; DOI=10.1016/j.neo.2021.05.008; PMCID=PMC8233172
Cornelia Fink, Nelli Baal, Jochen Wilhelm, Poonam Sarode, Roswitha Weigel, Valerie Schumacher, Daniel Nettersheim, Hubert Schorle, Carmen Schrock, Martin Bergmann, Sabine Kliesch ...Show all 13 authors... , Monika Kressin, Rajkumar Savai; Show fewer authors
On the origin of germ cell neoplasia in situ: dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro.
Neoplasia 23:731-742(2021)

PubMed=36899312; DOI=10.1186/s12885-023-10696-7; PMCID=PMC10007848
Birte Schulz, Valerie Schumacher, Anaclet Ngezahayo, Daniela Maier-Begandt, Nadine Schadzek, Jochen Wilhelm, Wolfgang Weidner, Adrian Pilatz, Daniela Fietz, Sabine Kliesch, Nadine Schnepel ...Show all 15 authors... , Nina Hambruch, Kristina Rode, Marion Langeheine, Ralph Brehm; Show fewer authors
Analysis of connexin 43, connexin 45 and N-cadherin in the human Sertoli cell line FS1 and the human seminoma-like cell line TCam-2 in comparison with human testicular biopsies.
BMC Cancer 23:232.1-232.20(2023)

Cross-references
Encyclopedic resources Wikidata; Q54971858
Experimental variables resources EFO; EFO_0022718
Gene expression databases GEO; GSM5209339
GEO; GSM5209340
GEO; GSM5209341
GEO; GSM5209342
GEO; GSM5209343
GEO; GSM5209344
GEO; GSM5209345
GEO; GSM5209346
Polymorphism and mutation databases Cosmic; 1449155
Cosmic; 2077183
Cosmic; 2163764
Cosmic; 2806820
Cosmic; 2807076
Entry history
Entry creation03-Feb-2014
Last entry update10-Apr-2025
Version number18