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Cellosaurus HAP1 MKI67 (-) 4 (CVCL_SY46)

[Text version]
Cell line name HAP1 MKI67 (-) 4
Synonyms HZGHC000982c009; MKI67 knockout cell line 2bp insertion
Accession CVCL_SY46
Resource Identification Initiative To cite this cell line use: HAP1 MKI67 (-) 4 (RRID:CVCL_SY46)
Comments Group: Haploid karyotype cell line.
Knockout cell: Method=CRISPR/Cas9; HGNC; 7107; MKI67.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Y019 (HAP1)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Horizon_Discovery; HZGHC000982c009
Cell line databases/resources cancercelllines; CVCL_SY46
Encyclopedic resources Wikidata; Q54876377
Entry history
Entry creation14-May-2018
Last entry update05-Oct-2023
Version number9