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Cellosaurus HAP1 INPP5E (-) 2 (CVCL_SS69)

[Text version]
Cell line name HAP1 INPP5E (-) 2
Synonyms HZGHC002902c002; INPP5E knockout cell line 1bp deletion
Accession CVCL_SS69
Resource Identification Initiative To cite this cell line use: HAP1 INPP5E (-) 2 (RRID:CVCL_SS69)
Comments Group: Haploid karyotype cell line.
Knockout cell: Method=CRISPR/Cas9; HGNC; 21474; INPP5E.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Y019 (HAP1)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Publications

PubMed=28031327; DOI=10.1128/mcb.00500-16
Sierra Potchanant E.A., Cerabona D., Sater Z.A., He Y., Sun Z.-J., Gehlhausen J., Nalepa G.
INPP5E preserves genomic stability through regulation of mitosis.
Mol. Cell. Biol. 37:e00500.16.1-e00500.16.21(2017)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HZGHC002902c002
Cell line databases/resources cancercelllines; CVCL_SS69
Encyclopedic resources Wikidata; Q54875764
Entry history
Entry creation14-May-2018
Last entry update05-Oct-2023
Version number10