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Cellosaurus HAP1 BLVRB (-) 3 (CVCL_SF29)

[Text version]
Cell line name HAP1 BLVRB (-) 3
Synonyms HZGHC003760c010; BLVRB knockout cell line 10bp deletion
Accession CVCL_SF29
Resource Identification Initiative To cite this cell line use: HAP1 BLVRB (-) 3 (RRID:CVCL_SF29)
Comments Group: Haploid karyotype cell line.
Knockout cell: Method=CRISPR/Cas9; HGNC; 1063; BLVRB.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Y019 (HAP1)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Publications

PubMed=31659326; DOI=10.1038/s41592-019-0614-5
Smits A.H., Ziebell F., Joberty G., Zinn N., Mueller W.F., Clauder-Munster S., Eberhard D., Falth Savitski M., Grandi P., Jakob P., Michon A.-M., Sun H., Tessmer K., Burckstummer T., Bantscheff M., Steinmetz L.M., Drewes G., Huber W.
Biological plasticity rescues target activity in CRISPR knock outs.
Nat. Methods 16:1087-1093(2019)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HZGHC003760c010
Encyclopedic resources Wikidata; Q54872971
Gene expression databases ArrayExpress; E-MTAB-7061
Proteomic databases PRIDE; PXD010335
Entry history
Entry creation14-May-2018
Last entry update29-Jun-2023
Version number9