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Cellosaurus C170 (CVCL_S959)

[Text version]
Cell line name C170
Accession CVCL_S959
Resource Identification Initiative To cite this cell line use: C170 (RRID:CVCL_S959)
Comments Doubling time: 26 +- 0.5 hours (PubMed=3947514).
Microsatellite instability: Instable (MSI) (PubMed=25926053).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,24:02
HLA-BB*08:01,35:01
HLA-CC*04:01,07:01
Disease Colorectal adenocarcinoma (NCIt: C5105)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25877200; PubMed=25926053

Markers:
AmelogeninX,Y
CSF1PO12
D3S135817
D5S81813
D7S82010,12
D8S117915
D13S3178,11
D16S53912,13
D18S5111,17
D21S1129,32.2
FGA22
Penta D9,14
Penta E7,14
TH017,9.3
TPOX8,11
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=3947514; DOI=10.1038/bjc.1986.6; PMCID=PMC2001479
Lindy G. Durrant, R. Adrian Robins, Malcolm V. Pimm, Alan C. Perkins, Nicholas C.M. Armitage, Jack Donald Hardcastle, Robert W. Baldwin;
Antigenicity of newly established colorectal carcinoma cell lines.
Br. J. Cancer 53:37-45(1986)

PubMed=3435698; DOI=10.1038/bjc.1987.277; PMCID=PMC2002417
Lindy G. Durrant, Mathew C. Garnett, J. Gallego, Nicholas C.M. Armitage, Kenneth C. Ballantyne, Ruth A. Marksman, Jack Donald Hardcastle, Robert W. Baldwin;
Sensitivity of newly established colorectal cell lines to cytotoxic drugs and monoclonal antibody drug conjugates.
Br. J. Cancer 56:722-726(1987)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

Cross-references
Cell line databases/resources CLO; CLO_0009954
cancercelllines; CVCL_S959
ColonAtlas; C170
LINCS_LDP; LCL-1156
Biological sample resources BioSample; SAMN03473189
Chemistry resources ChEMBL-Cells; CHEMBL3308628
ChEMBL-Targets; CHEMBL614705
PharmacoDB; C170_152_2019
PubChem_Cell_line; CVCL_S959
Encyclopedic resources Wikidata; Q54807871
Experimental variables resources EFO; EFO_0006363
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM206448
GEO; GSM274834
GEO; GSM513927
GEO; GSM514181
GEO; GSM827320
GEO; GSM1448107
Polymorphism and mutation databases Progenetix; CVCL_S959
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation03-Feb-2014
Last entry update10-Apr-2025
Version number23