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Cellosaurus SEMK2-M1 (CVCL_S907)

[Text version]
Cell line name SEMK2-M1
Accession CVCL_S907
Resource Identification Initiative To cite this cell line use: SEMK2-M1 (RRID:CVCL_S907)
Comments Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:7135; AFF1 + HGNC; HGNC:7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4 (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged (NCIt: C80342)
B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) (ORDO: Orphanet_585918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S906 (SEMK2)
Sex of cell Female
Age at sampling 5Y
Category Cancer cell line
Publications

PubMed=12620411; DOI=10.1016/S1535-6108(03)00003-5
Scott Allen Armstrong, Andrew Li-Jen Kung, Meghann E. Mabon, Lewis B. Silverman, Ronald W. Stam, Monique L. den Boer, Robrecht Pieters, John H. Kersey, Stephen Earl Sallan, Jonathan A. Fletcher, Todd Robert Golub ...Show all 13 authors... , James Douglas Griffin, Stanley Joel Korsmeyer; Show fewer authors
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification.
Cancer Cell 3:173-183(2003)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S907
Encyclopedic resources Wikidata; Q54952798
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number19