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Cellosaurus HCC4011/R (CVCL_S747)

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Cell line name HCC4011/R
Synonyms HCC4011/ER; HCC4011R
Accession CVCL_S747
Resource Identification Initiative To cite this cell line use: HCC4011/R (RRID:CVCL_S747)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Unspecified (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S700 (HCC4011)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=22773810; DOI=10.1073/pnas.1203530109; PMCID=PMC3411967
Kadoaki Ohashi, Lecia VanDam Sequist, Maria E. Arcila, Teresa Moran, Juliann Chmielecki, Ya-Lun Lin, Yu-Mei Pan, Lu Wang, Elisa de Stanchina, Kazuhiko Shien, Keisuke Aoe ...Show all 24 authors... , Shinichi Toyooka, Katsuyuki Kiura, Lynnette Fernandez-Cuesta, Panos Fidias, James Chih-Hsin Yang, Vincent A. Miller, Gregory J. Riely, Mark G. Kris, Jeffrey Adam Engelman, Cindy L. Vnencak-Jones, Dora Dias-Santagata, Marc Ladanyi, William Pao; Show fewer authors
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
Proc. Natl. Acad. Sci. U.S.A. 109:E2127-E2133(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S747
Encyclopedic resources Wikidata; Q54881734
Polymorphism and mutation databases Cosmic; 1890458
Entry history
Entry creation03-Feb-2014
Last entry update14-Aug-2025
Version number13