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Cellosaurus 11-18/R (CVCL_S745)

[Text version]
Cell line name 11-18/R
Synonyms 11-18R; 11-18/ER
Accession CVCL_S745
Resource Identification Initiative To cite this cell line use: 11-18/R (RRID:CVCL_S745)
Comments Population: Japanese and Micro.
Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=22773810).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6659 (11-18)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=22773810; DOI=10.1073/pnas.1203530109; PMCID=PMC3411967
Kadoaki Ohashi, Lecia VanDam Sequist, Maria E. Arcila, Teresa Moran, Juliann Chmielecki, Ya-Lun Lin, Yu-Mei Pan, Lu Wang, Elisa de Stanchina, Kazuhiko Shien, Keisuke Aoe ...Show all 24 authors... , Shinichi Toyooka, Katsuyuki Kiura, Lynnette Fernandez-Cuesta, Panos Fidias, James Chih-Hsin Yang, Vincent A. Miller, Gregory J. Riely, Mark G. Kris, Jeffrey Adam Engelman, Cindy L. Vnencak-Jones, Dora Dias-Santagata, Marc Ladanyi, William Pao; Show fewer authors
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
Proc. Natl. Acad. Sci. U.S.A. 109:E2127-E2133(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S745
Encyclopedic resources Wikidata; Q54554912
Polymorphism and mutation databases Cosmic; 1890459
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number16