Cell line name |
p53HCT116 |
Synonyms |
P53HCT116; p53-/- HCT116; p53(-/-) HCT-116; HCT116-p53-/-; HCT116-p53 |
Accession |
CVCL_S744 |
Resource Identification Initiative |
To cite this cell line use: p53HCT116 (RRID:CVCL_S744) |
Comments |
Population: Caucasian. Knockout cell: Method=Gamma radiation; HGNC; HGNC:11998; TP53. Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
Disease |
Colon carcinoma (NCIt: C4910) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0291 (HCT 116) |
Sex of cell |
Male |
Age at sampling |
48Y |
Category |
Cancer cell line |
Publications | PubMed=9822382; DOI=10.1126/science.282.5393.1497 Fred Bunz, Annie Dutriaux, Christoph Lengauer, Todd A. Waldman, Shi-Bin Zhou, Joseph P. Brown, John Michael Sedivy, Kenneth Wayne Kinzler, Bert Vogelstein; Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282:1497-1501(1998) PubMed=19927377; DOI=10.1002/gcc.20730; PMCID=PMC2818350 Turid Knutsen, Hesed Maria Padilla-Nash, Danny Wangsa, Linda Barenboim-Stapleton, Jordi Camps, Nicole E. McNeil, Michael J. Difilippantonio, Thomas Ried; Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines. Genes Chromosomes Cancer 49:204-223(2010) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_S744
SKY/M-FISH/CGH; 1688
SKY/M-FISH/CGH; 2781
|
Encyclopedic resources |
Wikidata; Q54937306
|
Polymorphism and mutation databases |
Cosmic; 1132690
|
Entry history |
Entry creation | 03-Feb-2014 |
Last entry update | 19-Dec-2024 |
Version number | 16 |
---|