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Cellosaurus EWS-502 (CVCL_S740)

[Text version]
Cell line name EWS-502
Synonyms EWS/502; EWS502
Accession CVCL_S740
Resource Identification Initiative To cite this cell line use: EWS-502 (RRID:CVCL_S740)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Fletcher, Jonathan A.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School; Boston; USA.
Population: Caucasian.
Doubling time: 46 hours (PubMed=25984343).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; shRNA library screening.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African5.9
Native American0
East Asian, North4.68
East Asian, South0
South Asian0
European, North38.28
European, South51.14
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=16766266; DOI=10.1016/j.ccr.2006.04.021
Ian J. Davis, Jessica J. Kim, Fatih Ozsolak, Hans R. Widlund, Orit Rozenblatt-Rosen, Scott R. Granter, Jin-Yan Du, Jonathan A. Fletcher, Christopher T. Denny, Stephen Lee Lessnick, William Marston Linehan ...Show all 13 authors... , Andrew Li-Jen Kung, David Erich Fisher; Show fewer authors
Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.
Cancer Cell 9:473-484(2006)

PubMed=23145994; DOI=10.1186/1471-2407-12-513; PMCID=PMC3519708
Babu Jully, Vijayalakshmi Ramshankar, Gopal Gopisetty, Kesavan Sabitha, Thangarajan Rajkumar;
Junction region of EWS-FLI1 fusion protein has a dominant negative effect in Ewing's sarcoma in vitro.
BMC Cancer 12:513.1-513.10(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=29866822; DOI=10.1073/pnas.1802079115; PMCID=PMC6016782
Matthew L. Hemming, Matthew A. Lawlor, Rhamy Zeid, Tom Lesluyes, Jonathan A. Fletcher, Chandrajit P. Raut, Ewa T. Sicinska, Frederic Chibon, Scott Allen Armstrong, George Daniel Demetri, James E. Bradner;
Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome.
Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S740
Cell_Model_Passport; SIDM01499
DepMap; ACH-000279
Biological sample resources BioSample; SAMN10988395
CRISP screens repositories BioGRID_ORCS_Cell_line; 174
Chemistry resources PharmacoDB; EWS502_362_2019
Encyclopedic resources Wikidata; Q54833006
Gene expression databases GEO; GSM2527268
GEO; GSM2527269
Polymorphism and mutation databases Cosmic; 2294584
Progenetix; CVCL_S740
Entry history
Entry creation03-Feb-2014
Last entry update10-Apr-2025
Version number23