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Cellosaurus HCC827-GR-high1 (CVCL_S703)

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Cell line name HCC827-GR-high1
Accession CVCL_S703
Resource Identification Initiative To cite this cell line use: HCC827-GR-high1 (RRID:CVCL_S703)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=23542356; DOI=10.1158/0008-5472.CAN-12-4136; PMCID=PMC4506773
Kazuhiko Shien, Shinichi Toyooka, Hiromasa Yamamoto, Junichi Soh, Masaru Jida, Kelsie L. Thu, Shinsuke Hashida, Yuho Maki, Eiki Ichihara, Hiroaki Asano, Kazunori Tsukuda ...Show all 16 authors... , Nagio Takigawa, Katsuyuki Kiura, Adi F. Gazdar, Wan L. Lam, Shinichiro Miyoshi; Show fewer authors
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.
Cancer Res. 73:3051-3061(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S703
Encyclopedic resources Wikidata; Q54881800
Polymorphism and mutation databases Cosmic; 1896426
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number16