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Cellosaurus HCC4006-GR-step (CVCL_S699)

[Text version]
Cell line name HCC4006-GR-step
Accession CVCL_S699
Resource Identification Initiative To cite this cell line use: HCC4006-GR-step (RRID:CVCL_S699)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu747_Glu749del (c.2239_2247delTAAGAGAA); ClinVar=VCV000177765; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr205His (c.613T>C); ClinVar=VCV000376685; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1269 (HCC4006)
Sex of cell Male
Age at sampling >50Y
Category Cancer cell line
Publications

PubMed=23542356; DOI=10.1158/0008-5472.CAN-12-4136; PMCID=PMC4506773
Kazuhiko Shien, Shinichi Toyooka, Hiromasa Yamamoto, Junichi Soh, Masaru Jida, Kelsie L. Thu, Shinsuke Hashida, Yuho Maki, Eiki Ichihara, Hiroaki Asano, Kazunori Tsukuda ...Show all 16 authors... , Nagio Takigawa, Katsuyuki Kiura, Adi F. Gazdar, Wan L. Lam, Shinichiro Miyoshi; Show fewer authors
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.
Cancer Res. 73:3051-3061(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S699
Encyclopedic resources Wikidata; Q54881726
Polymorphism and mutation databases Cosmic; 1896430
Entry history
Entry creation03-Feb-2014
Last entry update14-Aug-2025
Version number17