Cellosaurus cell line Ma-Mel-61c (CVCL

Cellosaurus Ma-Mel-61c (CVCL_S666)

Cross-references
Cell line name	Ma-Mel-61c
Accession	CVCL_S666
Resource Identification Initiative	To cite this cell line use: Ma-Mel-61c (RRID:CVCL_S666)
Comments	Omics: Variations; SNP array analysis. Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations	Gene deletion; HGNC; HGNC:6190; JAK1; Zygosity=Heterozygous (PubMed=28561041). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23348503).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_C291 ! Ma-Mel-61a CVCL_C292 ! Ma-Mel-61b CVCL_S667 ! Ma-Mel-61e CVCL_S668 ! Ma-Mel-61f CVCL_S669 ! Ma-Mel-61g CVCL_S670 ! Ma-Mel-61h
Sex of cell	Male
Age at sampling	29Y
Category	Cancer cell line
Publications	PubMed=23348503; DOI=10.1126/science.1230062 Susanne Horn, Adina Figl, P. Sivaramakrishna Rachakonda, Christine Fischer, Antje Sucker, Andreas Gast, Stephanie Kadel, Iris Moll, Eduardo Nagore, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar; TERT promoter mutations in familial and sporadic melanoma. Science 339:959-961(2013) PubMed=28561041; DOI=10.1038/ncomms15440; PMCID=PMC5460020 Antje Sucker, Fang Zhao, Natalia Pieper, Christina Heeke, Raffaela Maltaner, Nadine Stadtler, Birgit Real, Nicola Bielefeld, Sebastian Howe, Benjamin Weide, Ralf Gutzmer ...Show all 23 authors... , Jochen Sven Utikal, Carmen Loquai, Helen Gogas, Ludger Klein-Hitpass, Michael Zeschnigk, Astrid Maria Westendorf, Mirko Trilling, Susanne Horn, Bastian Schilling, Dirk Schadendorf, Klaus Georg Griewank, Annette Paschen; Show fewer authors Acquired IFNgamma resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions. Nat. Commun. 8:15440.1-15440.15(2017)
Cell line databases/resources	cancercelllines; CVCL_S666
Encyclopedic resources	Wikidata; Q54903830
Gene expression databases	GEO; GSM2545595
Polymorphism and mutation databases	Cosmic; 2686448 Progenetix; CVCL_S666
Entry history
Entry creation	03-Feb-2014
Last entry update	10-Apr-2025
Version number	14