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Cellosaurus GHOST(3).CCR5 (CVCL_S491)

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Cell line name GHOST(3).CCR5
Synonyms GHOST(3)-CCR5; GHOST CCR5; GHOST cell CCR5
Accession CVCL_S491
Resource Identification Initiative To cite this cell line use: GHOST(3).CCR5 (RRID:CVCL_S491)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; 1XF1B; GFP (Note=avGFP; original A.victoria green fluorescent protein).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1606; CCR5.
Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S489 (GHOST(3))
Children:
CVCL_LI03 (GHOST(3)-CCR5 DRiP78 and NHERF1 knockdown)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
Web pages Provider; NIBSC; 0078; http://www.nibsc.org/Default.aspx?pageid=597&ID=0078
Publications

PubMed=11878871; DOI=10.1006/viro.2001.1163
Dalma Vodros, Charlotte Tscherning-Casper, Leonor Navea, Dominique Schols, Erik De Clercq, Eva-Maria Fenyo;
Quantitative evaluation of HIV-1 coreceptor use in the GHOST3 cell assay.
Virology 291:1-11(2001)

PubMed=16061987; DOI=10.1385/1-59259-907-9:333
Dalma Vodros, Eva-Maria Fenyo;
Quantitative evaluation of HIV and SIV co-receptor use with GHOST(3) cell assay.
Methods Mol. Biol. 304:333-342(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S491
Chemistry resources ChEMBL-Cells; CHEMBL3308560
ChEMBL-Targets; CHEMBL614502
PubChem_Cell_line; CVCL_S491
Encyclopedic resources Wikidata; Q54835790
Entry history
Entry creation03-Feb-2014
Last entry update10-Apr-2025
Version number19