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Cellosaurus CHO-MK42 (CVCL_S408)

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Cell line name CHO-MK42
Synonyms CHO MK42; MK42
Accession CVCL_S408
Resource Identification Initiative To cite this cell line use: CHO-MK42 (RRID:CVCL_S408)
Comments Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_0214 (CHO-K1)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=281704; DOI=10.1073/pnas.75.11.5553; PMCID=PMC393004
Jack H. Nunberg, Randal J. Kaufman, Robert Tod Schimke, Gail Urlaub, Lawrence A. Chasin;
Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.
Proc. Natl. Acad. Sci. U.S.A. 75:5553-5556(1978)

PubMed=6287224; DOI=10.1128/mcb.2.1.93-96.1982; PMCID=PMC369757
Lloyd Herbert Graf Jr., Lawrence A. Chasin;
Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation.
Mol. Cell. Biol. 2:93-96(1982)

Cross-references
Encyclopedic resources Wikidata; Q54813080
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number10