| Cell line name |
MDA-MB-231 SimpleCell O-GalNAc |
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| Synonyms |
MDA-MB-231 SimpleCell; MDA-MB-231 SC |
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| Accession |
CVCL_S031 |
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| Resource Identification Initiative |
To cite this cell line use: MDA-MB-231 SimpleCell O-GalNAc (RRID:CVCL_S031) |
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| Comments |
Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
Knockout cell: Method=ZFN; HGNC; HGNC:24338; C1GALT1C1.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
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| Disease |
Breast adenocarcinoma (NCIt: C5214) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0062 (MDA-MB-231)
Children: |
| CVCL_S032 (MDA-MB-231 SimpleCell O-GalNAC/O-Man) |
|
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| Sex of cell |
Female |
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| Age at sampling |
51Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=23584533; DOI=10.1038/emboj.2013.79; PMCID=PMC3655468
Catharina Steentoft, Sergey Y. Vakhrushev, Hiren Jitendra Joshi, Yun Kong, Malene Bech Vester-Christensen, Katrine Ter-Borch Gram Schjoldager, Kirstine Lavrsen, Sally Dabelsteen, Nis B. Pedersen, Lara Marcos-Silva, Ramneek Gupta ...Show all 17 authors... , Eric Paul Bennett, Ulla Mandel, Soren Brunak, Hans Heugh Wandall, Steven Bruce Levery, Henrik Clausen; Show fewer authors
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.
EMBO J. 32:1478-1488(2013) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_S031
|
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| Encyclopedic resources |
Wikidata; Q54904590
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| Entry history |
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| Entry creation | 05-Nov-2013 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 25 |
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