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Cellosaurus K-562 SimpleCell O-GalNAc (CVCL_S029)

[Text version]
Cell line name K-562 SimpleCell O-GalNAc
Synonyms K562 SimpleCell; K562 SC
Accession CVCL_S029
Resource Identification Initiative To cite this cell line use: K-562 SimpleCell O-GalNAc (RRID:CVCL_S029)
Comments Population: Caucasian.
Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
Knockout cell: Method=ZFN; HGNC; HGNC:24338; C1GALT1C1.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=21983924; DOI=10.1038/nmeth.1731
Catharina Steentoft, Sergey Y. Vakhrushev, Malene Bech Vester-Christensen, Katrine Ter-Borch Gram Schjoldager, Yun Kong, Eric Paul Bennett, Ulla Mandel, Hans Heugh Wandall, Steven Bruce Levery, Henrik Clausen;
Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines.
Nat. Methods 8:977-982(2011)

PubMed=23399548; DOI=10.1074/mcp.O112.021972; PMCID=PMC3617340
Sergey Y. Vakhrushev, Catharina Steentoft, Malene Bech Vester-Christensen, Eric Paul Bennett, Henrik Clausen, Steven Bruce Levery;
Enhanced mass spectrometric mapping of the human GalNAc-type O-glycoproteome with SimpleCells.
Mol. Cell. Proteomics 12:932-944(2013)

PubMed=23584533; DOI=10.1038/emboj.2013.79; PMCID=PMC3655468
Catharina Steentoft, Sergey Y. Vakhrushev, Hiren Jitendra Joshi, Yun Kong, Malene Bech Vester-Christensen, Katrine Ter-Borch Gram Schjoldager, Kirstine Lavrsen, Sally Dabelsteen, Nis B. Pedersen, Lara Marcos-Silva, Ramneek Gupta ...Show all 17 authors... , Eric Paul Bennett, Ulla Mandel, Soren Brunak, Hans Heugh Wandall, Steven Bruce Levery, Henrik Clausen; Show fewer authors
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.
EMBO J. 32:1478-1488(2013)

Cross-references
Encyclopedic resources Wikidata; Q54899217
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number22