Cellosaurus cell line P7731 (CVCL

Cellosaurus P7731 (CVCL_RY01)

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Cell line name

P7731

Accession

CVCL_RY01

Resource Identification Initiative

To cite this cell line use: P7731 (RRID:CVCL_RY01)

Comments

Group: Triple negative breast cancer (TNBC) cell line.
Doubling time: ~24 hours (Direct_author_submission).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Miscellaneous: Doubling time and age of donor from personal communication of Chenevix-Trench, Georgia.
Miscellaneous: Conflicts in the STR profile of markers TH01 and vWA between PubMed=28889351 and PubMed=29468485 are clerical errors and are thus not recorded in the relevant section (personal communication of Chenevix-Trench, Georgia).
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.

Sequence variations

Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Unspecified (PubMed=28889351; PubMed=29468485).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys229Ter (c.687T>A); Zygosity=Unspecified (PubMed=28889351; PubMed=29468485).

Disease

Invasive breast carcinoma of no special type (NCIt: C4194)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

40Y

Category

Cancer cell line

STR profile

Source(s): PubMed=28889351; PubMed=29468485

Markers:

Amelogenin	X
CSF1PO	13,14
D5S818	9
D7S820	8,11
D13S317	11,12
D16S539	11
D21S11	31,31.2
TH01	8,9.3
TPOX	8,9
vWA	14,17

Publications

PubMed=28889351; DOI=10.1007/s10549-017-4496-x
Jodi M. Saunus, Chanel E. Smart, Jamie R. Kutasovic, Rebecca L. Johnston, Priyakshi Kalita-de Croft, Mariska Miranda, Esdy N. Rozali, Ana Cristina Vargas, Lynne E. Reid, Eva Lorsy, Sibylle Cocciardi ...Show all 23 authors... , Tatjana Seidens, Amy Ellen McCart Reed, Andrew J. Dalley, Leesa F. Wockner, Julie Johnson, Debina Sarkar, Marjan E. Askarian-Amiri, Peter T. Simpson, Kum Kum Khanna, Georgia Chenevix-Trench, Fares Al-Ejeh, Sunil R. Lakhani; Show fewer authors
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.
Breast Cancer Res. Treat. 167:289-301(2018)

PubMed=29468485; DOI=10.1007/s10549-018-4719-9
Julie Johnson, Darrell C. Bessette, Jodi M. Saunus, Chanel E. Smart, Sarah Song, Rebecca L. Johnston, Sibylle Cocciardi, Esdy N. Rozali, Cameron N. Johnstone, Ana Cristina Vargas, Stephen H. Kazakoff ...Show all 18 authors... , Kum Kum Khanna, Sunil R. Lakhani, Georgia Chenevix-Trench, Peter T. Simpson, Katia Nones, Nicola Waddell, Fares Al-Ejeh; Show fewer authors
Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient.
Breast Cancer Res. Treat. 170:179-188(2018)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_RY01

Encyclopedic resources

Wikidata; Q54937316

Gene expression databases

GEO; GSM2769404
GEO; GSM2769405
GEO; GSM2769406
GEO; GSM2785715

Polymorphism and mutation databases

Cosmic; 2814455

Sequence databases

EGA; EGAS00001002840

Entry history

Entry creation

05-Mar-2018

Last entry update

10-Apr-2025

Version number