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Cellosaurus 3L9 (CVCL_RX93)

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Cell line name 3L9
Accession CVCL_RX93
Resource Identification Initiative To cite this cell line use: 3L9 (RRID:CVCL_RX93)
Comments Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:6893; MAPT; Simple; c.1920+16C>T (c.2091+16C>T) (c.1866+16C>T) (c.915+16C>T) (c.828+16C>T) (IVS10+16C>T); ClinVar=VCV000098222; Zygosity=Unspecified (PubMed=27594586).
Disease Frontotemporal dementia (NCIt: C84719)
Behavioral variant of frontotemporal dementia (ORDO: Orphanet_275864)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_RX92 ! 3L6
Sex of cell Male
Age at sampling Age unspecified
Category Induced pluripotent stem cell
Publications

PubMed=27594586; DOI=10.1016/j.stemcr.2016.08.006; PMCID=PMC5032669
Mohammed Helal Uddin Biswas, Sandra Almeida, Rodrigo Lopez-Gonzalez, Wen-Jie Mao, Zhi-Jun Zhang, Anna M. Karydas, Michael David Geschwind, Jacek Biernat, Eva-Maria Mandelkow, Kensuke Futai, Bruce Lars Miller, Fen-Biao Gao;
MMP-9 and MMP-2 contribute to neuronal cell death in iPSC models of frontotemporal dementia with MAPT mutations.
Stem Cell Reports 7:316-324(2016)

Cross-references
Cell line databases/resources SKIP; SKIP001231
Encyclopedic resources Wikidata; Q54585543
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number10