| Cell line name |
MR49F |
| Synonyms |
MR49-F; ENZR 49F; 49FENZR |
| Accession |
CVCL_RW53 |
| Resource Identification Initiative |
To cite this cell line use: MR49F (RRID:CVCL_RW53) |
| Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_68534; Enzalutamide (Xtandi; MDV-3100). Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
| Sequence variations |
- Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
|
| Disease |
Prostate carcinoma (NCIt: C4863) |
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
| Hierarchy |
Parent: CVCL_0395 (LNCaP) |
| Sex of cell |
Male |
| Age at sampling |
50Y |
| Category |
Cancer cell line |
| Publications | PubMed=25428917; DOI=10.18632/oncotarget.2703; PMCID=PMC4381591 Jennifer L. Bishop, Alexander Sio, Arkhjamil Angeles, Morgan E. Roberts, Arun A. Azad, Kim N. Chi, Amina Zoubeidi; PD-L1 is highly expressed in enzalutamide resistant prostate cancer. Oncotarget 6:234-242(2015) PubMed=25634993; DOI=10.1158/1078-0432.CCR-14-1108 Yoshiaki Yamamoto, Yohann Loriot, Eliana Beraldi, Fan Zhang, Alexander W. Wyatt, Nader Al Nakouzi, Fan Mo, Tian-Yuan Zhou, Youngsoo Kim, Brett P. Monia, A. Robert MacLeod ...Show all 16 authors... , Ladan Fazli, Yu-Zhuo Wang, Colin C. Collins, Amina Zoubeidi, Martin E. Gleave; Show fewer authors Generation 2.5 antisense oligonucleotides targeting the androgen receptor and its splice variants suppress enzalutamide-resistant prostate cancer cell growth. Clin. Cancer Res. 21:1675-1687(2015) |
| Cross-references |
| Cell line databases/resources |
cancercelllines; CVCL_RW53
|
| Anatomy/cell type resources |
BTO; BTO_0006265
|
| Chemistry resources |
ChEMBL-Cells; CHEMBL4483149
ChEMBL-Targets; CHEMBL4483259
PubChem_Cell_line; CVCL_RW53
|
| Encyclopedic resources |
Wikidata; Q54906576
|
| Entry history |
| Entry creation | 05-Mar-2018 |
| Last entry update | 19-Dec-2024 |
| Version number | 12 |
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