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Cellosaurus MR49F (CVCL_RW53)

[Text version]
Cell line name MR49F
Synonyms MR49-F; ENZR 49F; 49FENZR
Accession CVCL_RW53
Resource Identification Initiative To cite this cell line use: MR49F (RRID:CVCL_RW53)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:68534; Enzalutamide (Xtandi; MDV-3100).
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line

PubMed=25428917; DOI=10.18632/oncotarget.2703
Bishop J.L., Sio A., Angeles A., Roberts M.E., Azad A.A., Chi K.N., Zoubeidi A.
PD-L1 is highly expressed in Enzalutamide resistant prostate cancer.
Oncotarget 6:234-242(2015)

PubMed=25634993; DOI=10.1158/1078-0432.CCR-14-1108
Yamamoto Y., Loriot Y., Beraldi E., Zhang F., Wyatt A.W., Al Nakouzi N., Mo F., Zhou T.-Y., Kim Y., Monia B.P., MacLeod A.R., Fazli L., Wang Y.-Z., Collins C.C., Zoubeidi A., Gleave M.E.
Generation 2.5 antisense oligonucleotides targeting the androgen receptor and its splice variants suppress enzalutamide-resistant prostate cancer cell growth.
Clin. Cancer Res. 21:1675-1687(2015)

Cell line databases/resources cancercelllines; CVCL_RW53
Anatomy/cell type resources BTO; BTO:0006265
Chemistry resources ChEMBL-Cells; CHEMBL4483149
ChEMBL-Targets; CHEMBL4483259
PubChem_Cell_line; CVCL_RW53
Encyclopedic resources Wikidata; Q54906576
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number11