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Cellosaurus H446/EP (CVCL_RT18)

[Text version]
Cell line name H446/EP
Accession CVCL_RT18
Resource Identification Initiative To cite this cell line use: H446/EP (RRID:CVCL_RT18)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Selected for resistance to: ChEBI; CHEBI_4911; Etoposide (VP-16).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:6728; LY6H + HGNC; HGNC:9709; PVT1; Name(s)=PVT1-LY6H (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly154Val (c.461G>T); ClinVar=VCV000651769; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1562 (NCI-H446)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
Publications

PubMed=28599409; DOI=10.3892/ol.2017.5967; PMCID=PMC5452998
Yi-Tian Chen, Xiang Yang, Yi-Chen Xu, Jiong-Rui Cao, Long-Bang Chen;
Genomic analysis of drug resistant small cell lung cancer cell lines by combining mRNA and miRNA expression profiling.
Oncol. Lett. 13:4077-4084(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RT18
Encyclopedic resources Wikidata; Q54872146
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number13