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Cellosaurus H69R (CVCL_RS65)

[Text version]
Cell line name H69R
Accession CVCL_RS65
Resource Identification Initiative To cite this cell line use: H69R (RRID:CVCL_RS65)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1579 (NCI-H69)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=27610620; DOI=10.1371/journal.pone.0162925; PMCID=PMC5017656
Yan F., Pang J.-X., Peng Y., Molina J.R., Yang P., Liu S.-J.
Elevated cellular PD1/PD-L1 expression confers acquired resistance to cisplatin in small cell lung cancer cells.
PLoS ONE 11:e0162925.1-e0162925.12(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RS65
Encyclopedic resources Wikidata; Q54872207
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number12