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Cellosaurus RT4rGEMCI10 (CVCL_RR20)

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Cell line name RT4rGEMCI10
Accession CVCL_RR20
Resource Identification Initiative To cite this cell line use: RT4rGEMCI10 (RRID:CVCL_RR20)
Comments Part of: Resistant Cancer Cell Line (RCCL) collection.
Population: Caucasian.
Doubling time: 56.2 hours (PubMed=26055179).
Selected for resistance to: ChEBI; CHEBI_175901; Gemcitabine (Gemzar).
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene fusion; HGNC; HGNC:3690; FGFR3 + HGNC; HGNC:11524; TACC3; Name(s)=FGFR3-TACC3 (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:12362; TSC1; Simple; p.Leu557Cysfs*72 (c.1669delC); ClinVar=VCV000048811; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0036 (RT-4)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
Web pages Provider; RCCL; -; https://www.wass-michaelislab.org/rccl.php
Publications

PubMed=26055179; DOI=10.1016/j.tranon.2015.04.002; PMCID=PMC4487788
Stefan Vallo, Martin Michaelis, Florian Rothweiler, Georg Bartsch, Kilian M. Gust, Dominik M. Limbart, Franz Rodel, Felix Wezel, Axel Haferkamp, Jindrich Cinatl Jr.;
Drug-resistant urothelial cancer cell lines display diverse sensitivity profiles to potential second-line therapeutics.
Transl. Oncol. 8:210-216(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RR20
Encyclopedic resources Wikidata; Q54951366
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number13