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Cellosaurus A549rCDDP2000 (CVCL_RQ47)

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Cell line name A549rCDDP2000
Accession CVCL_RQ47
Resource Identification Initiative To cite this cell line use: A549rCDDP2000 (RRID:CVCL_RQ47)
Comments Part of: Resistant Cancer Cell Line (RCCL) collection.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=28746345; DOI=10.1371/journal.pone.0181081; PMCID=PMC5528889
Navin Sarin, Florian Engel, Ganna V. Kalayda, Mareike Mannewitz, Jindrich Cinatl Jr., Florian Rothweiler, Martin Michaelis, Hisham Saafan, Christoph A. Ritter, Ulrich Jaehde, Roland Frotschl;
Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest.
PLoS ONE 12:e0181081.1-e0181081.26(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RQ47
Encyclopedic resources Wikidata; Q54607064
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number10