Cellosaurus cell line THJ560 (CVCL

Cellosaurus THJ560 (CVCL_RP40)

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Cell line name

THJ560

Accession

CVCL_RP40

Resource Identification Initiative

To cite this cell line use: THJ560 (RRID:CVCL_RP40)

Comments

Omics: Transcriptomics; Microarray.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=29846633; PubMed=30737244).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=29846633; PubMed=30737244).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Homozygous (PubMed=29846633; PubMed=30737244).

Disease

Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

49Y

Category

Cancer cell line

STR profile

Source(s): PubMed=29846633; PubMed=30737244

Markers:

Amelogenin	X
CSF1PO	9,10
D3S1358	16,17
D5S818	12
D7S820	10,12
D8S1179	12,14
D13S317	12
D16S539	9,14
D18S51	15
D21S11	29,32.2
FGA	24
TH01	6,7
TPOX	8
vWA	14

Publications

PubMed=29846633; DOI=10.1210/jc.2017-01845; PMCID=PMC6126888
Laura A. Marlow, Stephen Davis Rohl, James L. Miller, Jeffrey A. Knauf, James Alexander Fagin, Mabel M. Ryder, Dragana Milosevic, Brian C. Netzel, Stefan K.G. Grebe, Honey V. Reddi, Robert Christian Smallridge, John Alton Copland 3rd;
Methodology, criteria, and characterization of patient-matched thyroid cell lines and patient-derived tumor xenografts.
J. Clin. Endocrinol. Metab. 103:3169-3182(2018)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references

Cell line collections (Providers)

ABM; T8262

Cell line databases/resources

cancercelllines; CVCL_RP40

Encyclopedic resources

Wikidata; Q54972305

Entry history

Entry creation

05-Mar-2018

Last entry update

10-Apr-2025

Version number