Cellosaurus cell line JEM493 (CVCL

Cellosaurus JEM493 (CVCL_RP37)

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Cell line name

JEM493

Accession

CVCL_RP37

Resource Identification Initiative

To cite this cell line use: JEM493 (RRID:CVCL_RP37)

Comments

Omics: Transcriptomics; Microarray.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.

Sequence variations

Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000160364; Zygosity=Homozygous (PubMed=29846633; PubMed=30737244).
Mutation; HGNC; HGNC:17087; ICOSLG; Simple; p.Glu153Ter (c.457G>T); Zygosity=Heterozygous (PubMed=30737244).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=29846633; PubMed=30737244).

Disease

Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

75Y

Category

Cancer cell line

STR profile

Source(s): PubMed=29846633; PubMed=30737244

Markers:

Amelogenin	X,Y
CSF1PO	10,13
D3S1358	16,17
D5S818	12,14
D7S820	12
D8S1179	11,14
D13S317	11,12
D16S539	12
D18S51	12,19
D21S11	28,29
FGA	19,24
TH01	7
TPOX	8,11
vWA	14,15

Publications

PubMed=29846633; DOI=10.1210/jc.2017-01845; PMCID=PMC6126888
Laura A. Marlow, Stephen Davis Rohl, James L. Miller, Jeffrey A. Knauf, James Alexander Fagin, Mabel M. Ryder, Dragana Milosevic, Brian C. Netzel, Stefan K.G. Grebe, Honey V. Reddi, Robert Christian Smallridge, John Alton Copland 3rd;
Methodology, criteria, and characterization of patient-matched thyroid cell lines and patient-derived tumor xenografts.
J. Clin. Endocrinol. Metab. 103:3169-3182(2018)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references

Cell line collections (Providers)

ABM; T8260

Cell line databases/resources

cancercelllines; CVCL_RP37

Encyclopedic resources

Wikidata; Q54898571

Entry history

Entry creation

05-Mar-2018

Last entry update

10-Apr-2025

Version number