Cellosaurus cell line APP1E311 (CVCL

Cellosaurus APP1E311 (CVCL_RN68)

Cross-references
Cell line name	APP1E311
Synonyms	APP1E 311
Accession	CVCL_RN68
Resource Identification Initiative	To cite this cell line use: APP1E311 (RRID:CVCL_RN68)
Comments	Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:620; APP; Simple; p.Glu693del (c.2079_2081delAGA); Zygosity=Homozygous (PubMed=23434393).
Disease	Alzheimer's disease 1 (NCIt: C146894) Early-onset autosomal dominant Alzheimer disease (ORDO: Orphanet_1020)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_RN66 ! APP1E111 CVCL_RN67 ! APP1E211
Sex of cell	Female
Age at sampling	59Y
Category	Induced pluripotent stem cell
Publications	PubMed=23434393; DOI=10.1016/j.stem.2013.01.009 Kondo T., Asai M., Tsukita K., Kutoku Y., Ohsawa Y., Sunada Y., Imamura K., Egawa N., Yahata N., Okita K., Takahashi K., Asaka I., Aoi T., Watanabe A., Watanabe K., Kadoya C., Nakano R., Watanabe D., Maruyama K., Hori O., Hibino S., Choshi T., Nakahata T., Hioki H., Kaneko T., Naitoh M., Yoshikawa K., Yamawaki S., Suzuki S., Hata R., Ueno S.-i., Seki T., Kobayashi K., Toda T., Murakami K., Irie K., Klein W.L., Mori H., Asada T., Takahashi R., Iwata N., Yamanaka S., Inoue H. Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness. Cell Stem Cell 12:487-496(2013)
Encyclopedic resources	Wikidata; Q54750320
Entry history
Entry creation	05-Mar-2018
Last entry update	10-Apr-2025
Version number	10