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Cellosaurus MC-B11/14IgA- (CVCL_RN13)

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Cell line name MC-B11/14IgA-
Accession CVCL_RN13
Resource Identification Initiative To cite this cell line use: MC-B11/14IgA- (RRID:CVCL_RN13)
Comments Characteristics: Produces Ig kappa.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:5478; IGHA1.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Plasma cell; CL=CL_0000786.
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_RN12 (MC-B11/14)
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
Publications

PubMed=29030084; DOI=10.1016/j.exphem.2017.09.010; PMCID=PMC5716910
Denise K. Walters, Bonnie K. Arendt, Renee C. Tschumper, Xiao Wu, Diane F. Jelinek;
Characterization and use of the novel human multiple myeloma cell line MC-B11/14 to study biological consequences of CRISPR-mediated loss of immunoglobulin A heavy chain.
Exp. Hematol. 57:42-49.e1(2018)

Cross-references
Encyclopedic resources Wikidata; Q54904178
Entry history
Entry creation05-Mar-2018
Last entry update14-Aug-2025
Version number8